Improving Science Quality through the Replacement, Reduction and Refinement of Animals in Biomedical Research and Development

The 3Rs (Replacement, Reduction, and Refinement) of animals in research is a key topic for all researchers. This paper covers topics such as barriers and misconceptions that impede implementation of the 3Rs, tools to support the better design of experiments, and examples of how new technological and scientific approaches may contribute to the 3Rs.